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M94A1978.TXT
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1994-10-24
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Document 1978
DOCN M94A1978
TI Predicting depression in HIV disorder. HNRC Group.
DT 9412
AU Atkinson JH; Patterson TL; Chandler JL; Grant I; Sciolla A; University
of California San Diego, Department of Psychiatry; (0603), UCSD School
of Medicine, La Jolla 92093-0603.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):408 (abstract no. PD0238). Unique
Identifier : AIDSLINE ICA10/94370597
AB OBJECTIVE: To determine two year risk and predictors of major depression
in human immunodeficiency virus (HIV) infected (HIV+) men and
seronegative (HIV-) controls. METHODS: HIV+ (N = 136) and HIV- (N = 44)
men participating in a longitudinal cohort study were examined annually
for personal and family history of mood disorder (Structured Clinical
Interview for DSM-III-R [SCID]; Family History RDC), neuropsychological
(NP) status, magnetic resonance imaging (MRI), coping (Ways of Coping),
and marked life adversity (Brown & Harris). Likelihood of major
depression was computed by survival analysis and predictors were
determined from a Cox proportional hazards model. RESULTS: Kaplan-Meier
plot for time to major depression indicated overall (HIV+ and HIV-) risk
of 7% for each six-month interval on study. Time to episode of
depression was related to premorbid history of major depression (logrank
test, p < .001) and avoidant coping (p < .01) with life circumstances in
the six months preceding the depressive episode, but not to serostatus,
NP or MRI abnormality, or family history or life adversity. The two
years cumulative risk was 48% for those with past history vs. 19% for
those without prior major depression. CONCLUSION: Careful psychiatric
history-taking and coping assessment is crucial to identifying high risk
for mood disorders in HIV.
DE Comparative Study Depression/*EPIDEMIOLOGY Depressive
Disorder/*EPIDEMIOLOGY Human HIV Infections/*PSYCHOLOGY *HIV
Seronegativity HIV Seropositivity/*PSYCHOLOGY Male Neuropsychological
Tests Probability Prognosis Proportional Hazards Models Risk Factors
Survival Analysis MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).